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中国生物制药(01177.HK)：KRAS G12C抑制剂“GARSORASIB(D-1553片)”II期临床研究数据公布

China Biopharmaceutical (01177.HK): KRAS G12C inhibitor “GARSORASIB (D-1553 tablets)” Phase II clinical study data released

Gelonghui Finance · Apr 10 18:20

SINO BIOPHARM -3.91%

格隆汇4月11日丨中国生物制药(01177.HK)发布公告，集团联合开发的KRAS G12C抑制剂“garsorasib(D-1553片)”已在2024年美国癌症协会年会(AACR)公布II期临床试验(NCT05383898)的最新成果，用于KRAS G12C突变的非小细胞肺癌(NSCLC)患者。

此项研究结果表明，在经抗PD-(L)1治疗和含铂化疗后的局部晚期或转移性NSCLC患者中， garsorasib的客观缓解率(ORR)为50%，疾病控制率(DCR)为89%，中位缓解持续时间(DOR)为12.8个月，中位无进展生存期(PFS)为7.6个月。

Gelonghui, April 11 | China Biopharmaceutical (01177.HK) announced that the KRAS G12C inhibitor “garsorasib (D-1553 tablets)” jointly developed by the Group has announced the latest results of the phase II clinical trial (NCT05383898) at the 2024 American Cancer Association Annual Meeting (AACR) for non-small cell lung cancer (NSCLC) patients with KRAS G12C mutations.

The results of this study showed that in patients with locally advanced or metastatic NSCLC after anti-PD- (L) 1 treatment and platinum-containing chemotherapy, the objective remission rate (ORR) of garsorasib was 50%, the disease control rate (DCR) was 89%, the median duration of remission (DOR) was 12.8 months, and the median progression-free survival (PFS) was 7.6 months.

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