Summary by Moomoo AI
RedHill Biopharma Ltd., a specialty biopharmaceutical company, announced on February 20, 2024, the publication of new data in the International Journal of Molecular Sciences demonstrating that its investigational drug opaganib significantly improves long-term survival in a mouse model of lung damage following ionizing radiation exposure. The study indicates opaganib's potential as a medical countermeasure against radiation-induced lung inflammation and fibrosis. Opaganib, a selective sphingosine kinase-2 (SPHK2) inhibitor, is being developed for multiple indications, including Acute Radiation Syndrome (ARS), COVID-19, and oncology. The U.S. National Institutes of Health's Radiation and Nuclear Countermeasures Program (RNCP) has selected opaganib for its Product Development Program. The drug, which is easy to administer and has a five-year shelf-life, could be stockpiled by governments for use in radiological or nuclear incidents, pending FDA approval. The publication also highlights opaganib's potential benefits in cancer radiotherapy and its host-directed mechanism, which may maintain efficacy against emerging viral variants.