Summary by Moomoo AI
Kozai Pharmaceuticals-B (stock code: 2171) announced a Phase 1b clinical trial update of its CAR-T cell candidate product satri-cel (R&D code: CT041) at the 2024 American Society of Clinical Oncology Annual Conference on Gastrointestinal Oncology (ASCO GI). The study evaluated the safety and efficacy of satri-cel in patients with Claudin18.2-positive late-stage gastric/gastroesophageal combined prostate cancer (GC/GEJ) or pancreatic cancer (PC). The results showed that satri-cel had good overall safety, with no dose-limiting toxicity (DLT) or treatment-related death observed, and complete relief was achieved in some patients. Currently, a 2-phase clinical trial is underway and 600×106 cells have been identified as the Phase 2 Recommended Dose (RP2D). As the first autologous Claudin18.2 CAR T cell therapy, satri-cel shows promise in patients with late GC/GEJ and PC after multiple treatments, said Kozai Pharmaceuticals. The company is committed to being a global leader in biopharmaceuticals, bringing innovative and differentiated cell therapies to cancer patients worldwide.