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Nuvectis Pharma Announces Upcoming Presentations at the 2024 American Association for Cancer Research Meeting

Nuvectis Pharma Announces Upcoming Presentations at the 2024 American Association for Cancer Research Meeting

Nuvectis Pharma宣佈即將在2024年美國癌症研究協會會議上發表演講
GlobeNewswire ·  03/19 08:00

Fort Lee, NJ, March 19, 2024 (GLOBE NEWSWIRE) -- Nuvectis Pharma, Inc. (NASDAQ: NVCT) ("Nuvectis" or the "Company"), a clinical-stage biopharmaceutical company focused on the development of innovative precision medicines for the treatment of serious conditions of unmet medical need in oncology, today announced upcoming presentations for NXP800 and NXP900 at the upcoming 2024 American Association for Cancer Research Meeting (2024 AACR), taking place from April 5th to April 10th in San Diego, California. Presentation details are below:

新澤西州李堡,2024年3月19日(GLOBE NEWSWIRE)——專注於開發用於治療腫瘤學醫療需求未得到滿足的嚴重疾病的臨床階段生物製藥公司Nuvectis Pharma, Inc.(納斯達克股票代碼:NVCT)(“Nuvectis” 或 “公司”)今天宣佈將在即將舉行的2024年美國癌症協會上推出 NXP800 和 NXP900 研究會議(2024 AACR)將於4月5日至4月10日在加利福尼亞州聖地亞哥舉行。演示詳情如下:

Abstract Title Poster Presentation Details
NXP800 Pharmacokinetic and pharmacodynamic evaluation of NXP800, a novel GCN2 activator, in a first in human clinical trial Session Title
First-in-Human Phase I Clinical Trials 1
Session Date / Time
April 8th, 1:30 - 5:00 PM
NXP800 Using acquired resistance to explore the mechanism of action of the integrated stress response/GCN2 activator NXP800 - a new developmental agent for platinum-resistant ARID1A mutant ovarian cancer Session Title
Cell Cycle, Transcription Regulation, and Anticancer Drug Action
Session Date / Time
April 7th, 1:30 - 5:00 PM
NXP800 Discovery of ARID1A loss as a patient biomarker for NXP800 – a developmental activator of the integrated stress response (ISR) and inhibitor of the HSF1 pathway in ovarian cancer Session Title
Predictive Biomarkers 6
Session Date / Time
April 9th, 1:30 - 5:00 PM
NXP800 A novel GCN2 kinase activator demonstrates therapeutic efficacy in preclinical PDX models of human cholangiocarcinoma Session Title
Novel Targets and Pathways
Session Date / Time
April 8th, 9:00 AM - 12:30 PM
NXP900 Src family kinase inhibition demonstrates antitumor activity in vitro and in patient-derived xenograft models of human cholangiocarcinoma Session Title
Kinase and Phosphatase Inhibitors 1
Session Date / Time
April 7th, 1:30 - 5:00 PM
NXP900 NXP900, a novel YES1/SRC kinase inhibitor in phase 1, demonstrates potent inhibition of proliferation in cell lines resistant to ALK and EGFR inhibitors Session Title
Kinase and Phosphatase Inhibitors 1
Session Date / Time
April 7th, 1:30 - 5:00 PM
摘要標題 海報展示詳情
NXP800 首次對新型 GCN2 激活劑 NXP800 進行藥代動力學和藥效學評估,這是人體臨床試驗中的首例 會話標題
首次人體 I 期臨床試驗 1
會話日期/時間
4 月 8 日第四,下午 1:30-5:00
NXP800 利用獲得性耐藥性探索綜合應激反應/GCN2 激活劑 NXP800 的作用機制,該活化劑是抗鉑的 ARID1A 突變體卵巢癌的新發育藥物 會話標題
細胞週期、轉錄調控和抗癌藥物作用
會話日期/時間
4 月 7 日第四,下午 1:30-5:00
NXP800 發現 ARID1A 流失作爲 NXP800 的患者生物標誌物——卵巢癌綜合應激反應 (ISR) 的發育激活劑和 HSF1 通路的抑制劑 會話標題
預測性生物標誌物 6
會話日期/時間
4 月 9 日第四,下午 1:30-5:00
NXP800 一種新型的GCN2激酶激活劑在人類膽管癌的臨床前PDX模型中顯示出治療功效 會話標題
新的靶標和途徑
會話日期/時間
4 月 8 日第四,上午 9:00-下午 12:30
NXP900 Src 家族激酶抑制在體外和患者衍生的人膽管癌異種移植模型中均顯示出抗腫瘤活性 會話標題
激酶和磷酸酶抑制劑 1
會話日期/時間
4 月 7 日第四,下午 1:30-5:00
NXP900 NXP900 是一種處於 1 期的新型 YES1/SRC 激酶抑制劑,可有效抑制對 ALK 和 EGFR 抑制劑產生耐藥的細胞系的增殖 會話標題
激酶和磷酸酶抑制劑 1
會話日期/時間
4 月 7 日第四,下午 1:30-5:00

About Nuvectis Pharma, Inc.

關於 Nuvectis Pharma, Inc.

Nuvectis Pharma, Inc. is a biopharmaceutical company focused on the development of innovative precision medicines for the treatment of serious conditions of unmet medical need in oncology. The Company is currently developing two drug candidates, NXP800 and NXP900. NXP800 is an oral small molecule GCN2 activator currently in a Phase 1b clinical trial for the treatment for platinum resistant, ARID1a-mutated ovarian carcinoma and in an investigator-sponsored clinical trial for the treatment of cholangiocarcinoma. The U.S. Food and Drug Administration ("FDA") granted Fast Track Designation to the NXP800 development program in platinum resistant, ARID1a-mutated ovarian carcinoma, and Orphan Drug Designation for the treatment of cholangiocarcinoma. NXP900 is a novel, small molecule SRC/YES1 kinase inhibitor currently undergoing a Phase 1a dose escalation study.

Nuvectis Pharma, Inc. 是一家生物製藥公司,專注於開發創新的精準藥物,用於治療腫瘤學醫療需求未得到滿足的嚴重疾病。該公司目前正在開發兩種候選藥物,NXP800 和 NXP900。NXP800 是一種口服小分子 GCN2 活化劑,目前正在進行治療鉑耐藥性、ARID1A 突變卵巢癌的 1b 期臨床試驗,以及一項由研究者贊助的治療膽管癌的臨床試驗。美國食品藥品監督管理局(“FDA”)授予鉑耐藥性、ARID1A 突變卵巢癌的 NXP800 開發項目的 Fast Track 認證以及用於治療膽管癌的孤兒藥認證。NXP900 是一種新型的小分子 SRC/YES1 激酶抑制劑,目前正在進行 1a 期劑量遞增研究。

Forward Looking Statements

前瞻性陳述

Certain statements in this press release constitute "forward-looking statements" within the meaning of the federal securities laws, which statements are subject to substantial risks and uncertainties. All statements, other than statements of historical fact, contained in this press release are forward-looking statements. Forward-looking statements contained in this press release may be identified by the use of words such as "anticipate," "believe," "contemplate," "could," "estimate," "expect," "intend," "seek," "may," "might," "plan," "potential," "predict," "project," "target," "aim," "should," "will," "would," or the negative of these words or other similar expressions, although not all forward-looking statements contain these words. Forward-looking statements are based on Nuvectis Pharma, Inc.'s current expectations, estimates, and projections about future events and trends that we believe may affect our business, financial condition, results of operations, prospects, business strategy, and financial needs. The outcome of the events described in these forward-looking statements are subject to inherent uncertainties, risks, assumptions, market and other conditions, and other factors that are difficult to predict and include statements regarding the preclinical data generated to date for NXP800 and NXP900, the Phase 1a data generated for NXP800 and the timing and clinical expectations for the NXP800 Phase 1b study, including statements regarding NXP800's potential ability to become a therapeutic option for the treatment of platinum-resistant, ARID1a-mutated ovarian carcinoma, cholangiocarcinoma, and potentially other cancer indications, and timing of and expectations for the Phase 1a study for NXP900. Further, certain forward-looking statements are based on assumptions as to future events that may not prove to be accurate. These and other risks and uncertainties are subject to market and other conditions and described more fully in the section titled "Risk Factors" in our 2022 Form 10-K filed with the Securities and Exchange Commission ("SEC"). However, these risks are not exhaustive and new risks and uncertainties emerge from time to time, and it is not possible for us to predict all risks and uncertainties that could have an impact on the forward-looking statements contained in this press release or other filings with the SEC. Any forward-looking statements contained in this press release speak only as of the date of this press release. We expressly disclaim any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in our expectations or any changes in events, conditions or circumstances on which any such statement is based, except as may be required by law, and we claim the protection of the safe harbor for forward-looking statements contained in the Private Securities Litigation Reform Act of 1995.

本新聞稿中的某些陳述構成聯邦證券法所指的 “前瞻性陳述”,這些陳述存在重大風險和不確定性。除歷史事實陳述外,本新聞稿中包含的所有陳述均爲前瞻性陳述。本新聞稿中包含的前瞻性陳述可以通過使用 “預測”、“相信”、“考慮”、“可以”、“估計”、“期望”、“打算”、“尋求”、“可能”、“可能”、“潛在”、“預測”、“項目”、“目標”、“應該”、“將”、“會” 或 “將” 等詞語來識別這些詞語或其他類似表述的否定詞,儘管並非所有前瞻性陳述都包含這些詞語。前瞻性陳述以 Nuvectis Pharma, Inc. 爲基礎。”我們當前對未來事件和趨勢的預期、估計和預測,我們認爲這些預期、估計和預測可能會影響我們的業務、財務狀況、經營業績、前景、業務戰略和財務需求。這些前瞻性陳述中描述的事件結果受固有的不確定性、風險、假設、市場和其他條件以及其他難以預測的因素的影響,包括關於 NXP800 和 NXP900 迄今爲止生成的臨床前數據、爲 NXP800 生成的1a期數據以及NXP800 1b期研究的時間和臨床預期的陳述,包括關於NXP800 可能成爲治療鉑耐藥Arid1A-1A的治療選擇的能力的陳述變異的卵巢癌、膽管癌和可能的其他癌症適應症,以及 NXP900 1a 期研究的時機和期望。此外,某些前瞻性陳述基於對未來事件的假設,這些假設可能不準確。這些以及其他風險和不確定性受市場和其他條件的影響,在我們向美國證券交易委員會(“SEC”)提交的2022年10-K表格中標題爲 “風險因素” 的部分中有更全面的描述。但是,這些風險並非詳盡無遺,並且不時出現新的風險和不確定性,我們無法預測所有可能影響本新聞稿或向美國證券交易委員會提交的其他文件中包含的前瞻性陳述的風險和不確定性。本新聞稿中包含的任何前瞻性陳述僅代表截至本新聞稿發佈之日。除非法律要求,否則我們明確表示不承擔任何義務或承諾公開發布此處包含的任何前瞻性陳述的任何更新或修訂,以反映我們預期的任何變化或任何此類陳述所依據的事件、條件或情況的任何變化,並且我們要求1995年《私人證券訴訟改革法》中包含的前瞻性陳述受到安全港的保護。

Company Contact

公司聯繫人

Ron Bentsur
Chairman, Chief Executive Officer and President
Tel: 201-614-3151
rbentsur@nuvectis.com

Ron Bentsur
董事長、首席執行官兼總裁
電話:201-614-3151
rbentsur@nuvectis.com

Media Relations Contact

媒體關係聯繫人

Christopher M. Calabrese
LifeSci Advisors
Tel: 917-680-5608
ccalabrese@lifesciadvisors.com

克里斯托弗·卡拉布雷斯
生命科學顧問
電話:917-680-5608
ccalabrese@lifesciadvisors.com


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