Gainers

• Engine Gaming and Media, Inc. (NASDAQ:GAME) rose 51% to $4.80 in pre-market trading after the company reported Q4 2021 and FY21 revenue was higher year over year.
• BIOLASE, Inc. (NASDAQ:BIOL) rose 38.6% to $0.5820 in pre-market trading after Nasdaq granted the company 180-day extension to meet minimum bid price requirement. The company also entered into favorable credit deal.
• Inspira Technologies Oxy B.H.N. Ltd. (NASDAQ:IINN) rose 32.5% to $3.79 in pre-market trading. Inspira Technologies Oxy, on Tuesday, posted a Q3 loss of $2.5 million.
• Pasithea Therapeutics Corp. (NASDAQ:KTTA) rose 29.6% to $7.26 in pre-market trading. Pasithea Therapeutics shares jumped 153% on Tuesday after the company announced its subsidiary Pasithea Clinics has been approved to provide esketamine nasal spray for the treatment of resistant depression in adults.
• Society Pass Incorporated (NASDAQ:SOPA) shares rose 15.8% to $12.95 in pre-market trading after dipping 71% on Tuesday.
• Pure Storage, Inc. (NASDAQ:PSTG) rose 15.1% to $31.40 in pre-market trading after the company reported better-than-expected Q3 EPS and sales results and issued Q4 and FY22 sales guidance above estimates.
• Gracell Biotechnologies Inc. (NASDAQ:GRCL) rose 13% to $8.80 in pre-market trading. Gracell Biotechnologies shares gained 22% on Tuesday after the company reported members of its senior management team intend to use personal funds to buy up to $2 million in company ADSs in the open market over the next 3 months.
• Longeveron Inc. (NASDAQ:LGVN) rose 11.9% to $19.27 in pre-market trading after tumbling 39% on Tuesday. The company last week announced the FDA granted Rare Pediatric Disease designation for Lomecel-B for the treatment of Hypoplastic Left Heart Syndrome.
• Isoray, Inc. (NYSE:ISR) rose 10.6% to $0.52 in pre-market trading. IsoRay recently reported quarterly losses of $0.02 per share.
• Golden Ocean Group Limited (NASDAQ:GOGL) rose 10.1% to $8.80 in pre-market trading after reporting Q3 results.
• Meiwu Technology Company Limited (NASDAQ:WNW) shares rose 9% to $3.40 in pre-market trading.
• HP Inc. (NYSE:HPQ) rose 7.2% to $34.51 in pre-market trading after the company reported better-than-expected results for its fourth quarter and issued strong earnings forecast for the current quarter.
• Adamis Pharmaceuticals Corporation (NASDAQ:ADMP) rose 7.1% to $0.8640 in pre-market trading. Adamis Pharmaceuticals recently said it regained compliance with NASDAQ continued listing requirements.

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Check out these big penny stock gainers and losers

Losers

• Nordstrom, Inc. (NYSE:JWN) shares fell 26.7% to $23.40 in pre-market trading after the company reported worse-than-expected Q3 sales results. Jefferies downgraded Nordstrom from Buy to Hold and lowered the price target from $48 to $30.
• Vallon Pharmaceuticals, Inc. (NASDAQ:VLON) fell 25.8% to $5.42 in pre-market trading after jumping over 80% on Tuesday.
• iSpecimen Inc. (NASDAQ:ISPC) fell 21.1% to $10.41 in pre-market trading. iSpecimen shares jumped over 48% on Tuesday on continued upward momentum after the company announced it has been contracted to support new advanced research on COVID-19 seeking insights on its transmissibility, variants, outcomes, and testing validity among multiple population segments.
• Outlook Therapeutics, Inc. (NASDAQ:OTLK) fell 21.1% to $1.23 in pre-market trading after the company reported a $10 million bought deal offering of common stock.
• The Gap, Inc. (NYSE:GPS) fell 19.7% to $18.86 in pre-market trading after the company reported worse-than-expected Q3 EPS and sales results and cut FY21 adjusted EPS guidance below estimates.
• Petros Pharmaceuticals, Inc. (NASDAQ:PTPI) fell 19.2% to $1.89 in pre-market trading after jumping over 75% on Tuesday.
• Anaplan, Inc. (NYSE:PLAN) shares fell 17.8% to $42.80 in pre-market trading after the company reported Q3 earnings results. Piper Sandler downgraded Anaplan from Overweight to Neutral and lowered the price target from $77 to $48.
• Qualigen Therapeutics, Inc. (NASDAQ:QLGN) fell 16.8% to $2.13 in pre-market trading after jumping around 105% on Tuesday.
• Aptevo Therapeutics Inc. (NASDAQ:APVO) fell 15.8% to $14.34 in pre-market trading. Aptevo Therapeutics shares climbed 163% on Tuesday after the company announced a clinical update for its Phase 1b Expansion trial evaluating APVO436 in the treatment of AML. Preliminary data observed to date includes one complete remission.
• MediciNova, Inc. (NASDAQ:MNOV) shares fell 14.9% to $3.76 in pre-market trading after surging 44% on Tuesday.
• Autodesk, Inc. (NASDAQ:ADSK) shares fell 13.8% to $262.00 in pre-market trading. Autodesk reported upbeat results for its third quarter, but issued disappointing guidance. Autodesk said it sees Q4 revenue of $1.185 billion to $1.2 billion and non-GAAP earnings of $1.41 to $1.47 per share.
• Esperion Therapeutics, Inc. (NASDAQ:ESPR) shares fell 13.6% to $8.64 in pre-market trading after surging over 40% on Tuesday.
• Clarus Therapeutics Holdings, Inc. (NASDAQ:CRXT) shares fell 12% to $5.05 in pre-market trading. Clarus Therapeutics shares jumped 43% on Tuesday after the company was granted a U.S. Patent titled 'Oral testosterone ester formulations and methods of treating testosterone deficiency comprising same.'
• Faraday Future Intelligent Electric Inc. (NASDAQ:FFIE) fell 10.1% to $5.91 in pre-market trading after the company received anticipated letter from Nasdaq regarding form 10-Q filing.
• Happiness Development Group Limited (NASDAQ:HAPP) fell 7% to $0.70 in pre-market trading after dropping 9% on Tuesday.