The following is a summary of the Theriva Biologics, Inc. (TOVX) Q4 2023 Earnings Call Transcript:

Financial Performance:

• Theriva Biologics reported a decrease in general and administrative expenses from $9.9 million to $7.1 million, a decrease of 28% for 2023.

• Research and development expenses increased from $11.7 million for 2022 to $14.3 million for 2023, which is primarily due to higher clinical trial expenses related to the VIRAGE Phase 2 trial of VCN-01 in PDAC.

• As of December 31, 2023, Theriva Biologics had $23.2 million in cash and cash equivalents, compared to $41.8 million as of December 31, 2022.

Business Progress:

• Theriva Biologics continues to build its oncology-focused portfolio, focusing on opportunities for its lead clinical candidate, VCN-01.

• The VIRAGE Phase 2b trial of VCN-01 showed positive safety and feasibility results with improved clinical outcomes, and it aims to complete enrolment in the first half of 2024.

• Completed patient treatments for the Phase 1 trial on retinoblastoma are expected to have follow-ups finalized by the first half of 2024.

• With plans to increase R&D expenses due to the enrolment and expansion of clinical trials, the company expects to sustain its cash runway into Q1, 2025.

• After enrolling patients in the second cohort for the Phase 1b/2a trial of SYN-004, expectations are for enrolment to complete in Q2, 2024.

• Multiple discussions are ongoing regarding potential partnerships for the VCN-01 platform, SYN-004 and SYN-020 programs.

• The focus remains on driving program advancement, effective cash management, and strategic options to drive additional shareholder value while delivering promising treatments for difficult to treat cancers.

More details: Theriva Biologics IR

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