Eledon Pharmaceuticals (NASDAQ:ELDN – Get Rating) and Puma Biotechnology (NASDAQ:PBYI – Get Rating) are both small-cap medical companies, but which is the better stock? We will contrast the two companies based on the strength of their valuation, institutional ownership, risk, earnings, analyst recommendations, dividends and profitability.
Profitability
This table compares Eledon Pharmaceuticals and Puma Biotechnology's net margins, return on equity and return on assets.
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Eledon Pharmaceuticals alerts:
| Net Margins | Return on Equity | Return on Assets |
| Eledon Pharmaceuticals | N/A | -25.14% | -24.13% |
| Puma Biotechnology | 4.50% | 84.14% | 4.78% |
Volatility & Risk
Eledon Pharmaceuticals has a beta of 1.83, indicating that its share price is 83% more volatile than the S&P 500. Comparatively, Puma Biotechnology has a beta of 0.92, indicating that its share price is 8% less volatile than the S&P 500.
Analyst Ratings
This is a breakdown of recent ratings for Eledon Pharmaceuticals and Puma Biotechnology, as provided by MarketBeat.
| Sell Ratings | Hold Ratings | Buy Ratings | Strong Buy Ratings | Rating Score |
| Eledon Pharmaceuticals | 0 | 0 | 4 | 0 | 3.00 |
| Puma Biotechnology | 0 | 0 | 1 | 0 | 3.00 |
Eledon Pharmaceuticals currently has a consensus price target of $22.00, indicating a potential upside of 848.28%. Puma Biotechnology has a consensus price target of $8.00, indicating a potential upside of 101.01%. Given Eledon Pharmaceuticals' higher probable upside, analysts plainly believe Eledon Pharmaceuticals is more favorable than Puma Biotechnology.
Insider and Institutional Ownership
45.6% of Eledon Pharmaceuticals shares are held by institutional investors. Comparatively, 60.6% of Puma Biotechnology shares are held by institutional investors. 13.8% of Eledon Pharmaceuticals shares are held by company insiders. Comparatively, 21.2% of Puma Biotechnology shares are held by company insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a company will outperform the market over the long term.
Valuation and Earnings
This table compares Eledon Pharmaceuticals and Puma Biotechnology's gross revenue, earnings per share (EPS) and valuation.
| Gross Revenue | Price/Sales Ratio | Net Income | Earnings Per Share | Price/Earnings Ratio |
| Eledon Pharmaceuticals | N/A | N/A | -$34.51 million | ($2.66) | -0.87 |
| Puma Biotechnology | $253.20 million | 0.72 | -$29.13 million | $0.22 | 18.09 |
Puma Biotechnology has higher revenue and earnings than Eledon Pharmaceuticals. Eledon Pharmaceuticals is trading at a lower price-to-earnings ratio than Puma Biotechnology, indicating that it is currently the more affordable of the two stocks.
Summary
Puma Biotechnology beats Eledon Pharmaceuticals on 9 of the 12 factors compared between the two stocks.
About Eledon Pharmaceuticals
(Get Rating)
Eledon Pharmaceuticals, Inc., clinical stage biopharmaceutical company, focuses on developing medicines for the patients living with autoimmune disease and amyotrophic lateral sclerosis (ALS), and requiring an organ or cell-based transplant. Its lead product candidate includes AT-1501, a humanized monoclonal antibody to target CD40 Ligand that is a molecule expressed on the surface of human immune system T cells, which is in Phase 2a clinical trials for the treatment of ALS, and Phase 2 clinical trials in islet cell transplantation for the treatment of type 1 diabetes. The company was formerly known as Novus Therapeutics, Inc. and changed its name to Eledon Pharmaceuticals, Inc. in January 2021. Eledon Pharmaceuticals, Inc. is headquartered in Irvine, California.
About Puma Biotechnology
(Get Rating)
Puma Biotechnology, Inc., a biopharmaceutical company, focuses on the development and commercialization of products to enhance cancer care in the United States and internationally. The company's drug candidates include PB272 neratinib (oral) for the patients with early stage HER2-overexpressed/amplified breast cancer; PB272 (neratinib, oral) for the use of neratinib in combination with capecitabine for the treatment of adult patients with advanced or metastatic HER2-positive breast cancer; PB272 (neratinib, oral) for HER2 mutation-positive solid tumors. It has a license agreement with Pfizer, Inc.; and sub-license agreement with Specialised Therapeutics Asia Pte Ltd., CANbridge BIOMED Limited, Pint Pharma International SA, Knight Therapeutics, Inc., Pierre Fabre Medicament SAS, and Bixink Therapeutics Co., Ltd. The company was founded in 2010 and is headquartered in Los Angeles, California.
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