Lumos Pharma (NASDAQ:LUMO – Get Rating) and ALX Oncology (NASDAQ:ALXO – Get Rating) are both small-cap medical companies, but which is the superior stock? We will contrast the two businesses based on the strength of their profitability, institutional ownership, earnings, risk, valuation, analyst recommendations and dividends.
Profitability
This table compares Lumos Pharma and ALX Oncology's net margins, return on equity and return on assets.
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| Net Margins | Return on Equity | Return on Assets |
| Lumos Pharma | N/A | -33.81% | -29.78% |
| ALX Oncology | N/A | -31.38% | -29.66% |
Volatility & Risk
Lumos Pharma has a beta of 1.23, meaning that its stock price is 23% more volatile than the S&P 500. Comparatively, ALX Oncology has a beta of 2.21, meaning that its stock price is 121% more volatile than the S&P 500.
Analyst Ratings
This is a summary of current ratings and recommmendations for Lumos Pharma and ALX Oncology, as reported by MarketBeat.com.
| Sell Ratings | Hold Ratings | Buy Ratings | Strong Buy Ratings | Rating Score |
| Lumos Pharma | 0 | 0 | 3 | 0 | 3.00 |
| ALX Oncology | 0 | 1 | 6 | 0 | 2.86 |
Lumos Pharma presently has a consensus target price of $24.00, suggesting a potential upside of 181.03%. ALX Oncology has a consensus target price of $39.83, suggesting a potential upside of 199.50%. Given ALX Oncology's higher probable upside, analysts plainly believe ALX Oncology is more favorable than Lumos Pharma.
Institutional & Insider Ownership
28.4% of Lumos Pharma shares are owned by institutional investors. Comparatively, 89.4% of ALX Oncology shares are owned by institutional investors. 21.2% of Lumos Pharma shares are owned by company insiders. Comparatively, 49.9% of ALX Oncology shares are owned by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company will outperform the market over the long term.
Valuation & Earnings
This table compares Lumos Pharma and ALX Oncology's gross revenue, earnings per share (EPS) and valuation.
| Gross Revenue | Price/Sales Ratio | Net Income | Earnings Per Share | Price/Earnings Ratio |
| Lumos Pharma | $230,000.00 | 311.90 | -$30.43 million | ($3.44) | -2.48 |
| ALX Oncology | $1.18 million | 459.27 | -$83.46 million | ($2.72) | -4.89 |
Lumos Pharma has higher earnings, but lower revenue than ALX Oncology. ALX Oncology is trading at a lower price-to-earnings ratio than Lumos Pharma, indicating that it is currently the more affordable of the two stocks.
Summary
ALX Oncology beats Lumos Pharma on 10 of the 13 factors compared between the two stocks.
About Lumos Pharma
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Lumos Pharma, Inc., a clinical-stage biopharmaceutical company, focuses on the development and commercialization of therapeutics for rare diseases. Its lead therapeutic candidate LUM-201 is an oral growth hormone secretagogue ibutamoren, which is in Phase 2 clinical trial for the treatment of pediatric growth hormone deficiency and other rare endocrine disorders. The company is headquartered in Austin, Texas.
About ALX Oncology
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ALX Oncology Holdings Inc., a clinical-stage immuno-oncology company, focuses on developing therapies for patients fighting cancer. Its lead product candidate is ALX148, a CD47 blocking therapeutic that is in Phase 1b/2 clinical trial used for the treatment of myelodysplastic syndromes; and for the treatment of acute myeloid leukemia and non-Hodgkin's lymphoma, as well as a range of solid tumor indications, including head and neck squamous cell carcinoma, human epidermal growth factor receptor 2 (HER2) positive gastric/gastroesophageal junction carcinoma, HER2-expressing breast cancer, and other solid tumors. The company's pre-clinical products include ALTA-002, a SIRPa TRAAC that offers ways to engage the innate and adaptive immune response to cancer. ALX Oncology Holdings Inc. has a collaboration agreement with Merck for a Phase 2 trial evaluating ALX148 in combination with pembrolizumab with and without chemotherapy in patients with head and neck cancer; Zymeworks on a Phase 1 trial evaluating ALX148 with the HER2-targeting bispecific antibody zanidatamab in patients with HER2-expressing breast cancer and other solid tumors; and Tallac Therapeutics for the development, manufacturing and commercialization of a novel class of cancer immunotherapeutics. It also has a license agreement with Selexis SA and Crystal Bioscience, Inc. The company was founded in 2015 and is headquartered in South San Francisco, California.
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