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Pliant Therapeutics' Drug Trial Shows Promise In Reversing Lung Fibrosis In Patients

Pliant Therapeutics' Drug Trial Shows Promise In Reversing Lung Fibrosis In Patients

Pliant Therapeutics的药物试验显示有望逆转患者的肺纤维化
Benzinga ·  05/14 10:39

On Tuesday, Pliant Therapeutics Inc (NASDAQ:PLRX) announced topline data from a Phase 2a PET Imaging trial of bexotegrast (PLN-74809) evaluating change in total collagen levels in the lungs of patients with idiopathic pulmonary fibrosis (IPF) characterized by excessive collagen deposition in the lung.

周二,Pliant Therapeutics Inc(纳斯达克股票代码:PLRX)公布了bexotegrast(PLN-74809)2a期PET成像试验的主要数据,该试验评估了以肺部胶原蛋白沉积过多为特征的特发性肺纤维化(IPF)患者肺部胶原蛋白总水平的变化。

Bexotegrast-treated patients showed reduced total lung collagen post-treatment as measured by positron emission tomography (PET) imaging, compared to increased total lung collagen in the placebo group, suggesting potential reversal of fibrosis.

与安慰剂组的肺胶原蛋白总量增加相比,通过正电子发射断层扫描(PET)成像测量,接受Bexotegrast治疗的患者在治疗后肺部胶原蛋白总量减少,这表明纤维化可能逆转。

After 12 weeks of treatment, bexotegrast-treated patients showed a reduction in standardized uptake value (SUV) of 68GA-CBP8 in the lung compared to an increase in placebo.

经过12周的治疗,与安慰剂的增加相比,接受bexotegrast治疗的患者肺中 68GA-CBP8 的标准摄取值(SUV)有所降低。

68GA-CBP8 is a PET ligand that binds to type 1 collagen.

68GA-CBP8 是一种与 1 型胶原蛋白结合的 PET 配体。

This reduction in SUV indicates reduced total lung collagen in the treated group, suggesting a potential reversal of fibrosis.

SUV的减少表明接受治疗组的肺部胶原蛋白总量减少,这表明纤维化有可能逆转。

Bexotegrast-treated patients demonstrated improvements in forced vital capacity (FVC) and reduced cough severity compared to placebo.

与安慰剂相比,接受Bexotegrast治疗的患者表现出强迫肺活量(FVC)的改善和咳嗽的严重程度降低。

The trial's exploratory efficacy endpoints assessed changes in FVC forced vital capacity percent predicted (FVCpp), patient-reported cough severity, and fibrosis biomarkers.

该试验的探索性疗效终点评估了FVC强制肺活量预测百分比(fvCPP)、患者报告的咳嗽严重程度和纤维化生物标志物的变化。

Bexotegrast-treated patients experienced improved lung function, as measured by FVC and FVCpp, with a clear separation from placebo.

根据FVC和fvCPP的测量,接受Bexotegrast治疗的患者的肺功能得到改善,与安慰剂明显分开。

Across all time points, bexotegrast-treated patients experienced reduced patient-reported cough severity compared to placebo patients.

在所有时间点上,与安慰剂患者相比,接受bexotegrast治疗的患者报告的咳嗽严重程度有所降低。

At weeks 4 and 12, bexotegrast-treated patients demonstrated a reduction in circulating biomarkers integrin beta-6 and PRO-C3 relative to placebo.

在第 4 周和第 12 周,与安慰剂相比,经过 bexotegrat 治疗的患者表现出循环生物标志物整合素 β-6 和 PRO-C3 的含量有所减少。

PRO-C3, a serum biomarker of type III collagen synthesis, is elevated in patients with IPF and associated with progressive disease.

PRO-C3 是 III 型胶原蛋白合成的血清生物标志物,在 IPF 患者中升高,与进行性疾病有关。

Bexotegrast was well tolerated at 160 mg over 12 weeks of treatment, with no serious adverse events reported.

在12周的治疗中,160毫克的Bexotegrast耐受性良好,没有报告严重的不良事件。

Most frequently reported treatment-emergent adverse events were mild in severity with no trial discontinuations.

最常报告的治疗紧急不良事件的严重程度较轻,没有中止试验。

Price Action: PLRX shares are up 1.3% at $13.90 at last check Tuesday.

价格走势:周二最后一次检查时,PLRX股价上涨1.3%,至13.90美元。

Photo: Shutterstock

照片:Shutterstock

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