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Zai Lab To Present Analysis Of The Impact Of Timing For ZEJULA Maintenance Treatment In Newly Diagnosed Advanced Ovarian Cancer At The 2022 International Gynecologic Cancer Society Meeting September 29 - October 1, 2022
Zai Lab To Present Analysis Of The Impact Of Timing For ZEJULA Maintenance Treatment In Newly Diagnosed Advanced Ovarian Cancer At The 2022 International Gynecologic Cancer Society Meeting September 29 - October 1, 2022
SHANGHAI and SAN FRANCISCO and CAMBRIDGE, Mass., Sept. 20, 2022 (GLOBE NEWSWIRE) -- Zai Lab Limited (NASDAQ:ZLAB, HKEX: 9688))))), a patient-focused, innovative, commercial-stage, global biopharmaceutical company, will present a poster featuring initiation timing analysis from the Phase 3 PRIME study of ZEJULA (niraparib) as maintenance therapy at the upcoming 2022 International Gynecologic Cancer Society (ICGS) Annual Meeting.
This post-hoc analysis of the PRIME Phase 3 study evaluated adults with newly diagnosed advanced ovarian cancer who responded to first-line platinum-based chemotherapy, and they were randomized to receive niraparib maintenance treatment or placebo within 12 weeks after chemotherapy completion. The results are as follows:
- For patients who received niraparib treatment less than 9 weeks after chemotherapy completion, the median progression-free survival (PFS) (95% CI) was measured at 29.4 months with niraparib versus 8.3 months with placebo (HR =0.31; 95% CI, 0.20–0.48).
- For patients who received niraparib at 9 – 12 weeks after chemotherapy completion, the median PFS was 24.7 months with niraparib versus 10.8 months with placebo (HR=0.60; 95% CI, 0.41–0.89).
- The initiation timing of niraparib maintenance treatment had no significant impact on its safety profile.
This subgroup analysis provides evidence to support the initiation of niraparib maintenance treatment in patients with newly diagnosed advanced ovarian cancer within 12 weeks after chemotherapy completion.
"We are excited to be presenting at the 2022 International Gynecologic Cancer Society Annual Meeting showing these results improved clinical efficacy when niraparib maintenance treatment is initiated within 12 weeks after chemotherapy in patients with advanced ovarian cancer," said Alan Sandler, M.D., President and Head of Global Development, Oncology, Zai Lab. "This study further supports ZEJULA as an important maintenance treatment therapy after platinum-based chemotherapy in people with advanced ovarian cancer."
"This PRIME study analysis will help support clinical practice in treating advanced ovarian cancer in China, showing niraparib extended progression-free survival when maintenance treatment begins within 12 weeks after chemotherapy," said Jing Wang, M.D., Director of the Early Clinical Research Center, Hunan Cancer Hospital. "Since a majority of women face recurrence of advanced ovarian cancer after chemotherapy, this study supports niraparib maintenance treatment having a significant clinical benefit in extending progression-free survival compared to placebo."
Details regarding the e-poster presentation at IGCS 2022 are as follows:
Abstract number: 876 Title: Impact of initiation timing of niraparib maintenance treatment in newly diagnosed advanced ovarian cancer Speaker: Jing Wang, M.D., Hunan Cancer Hospital Date: September 29-October 1, 2022 |
SHANGHAI and SAN FRANCISCO and CAMBRIDGE, Mass., Sept. 20, 2022 (GLOBE NEWSWIRE) -- Zai Lab Limited (NASDAQ:ZLAB, HKEX: 9688))))), a patient-focused, innovative, commercial-stage, global biopharmaceutical company, will present a poster featuring initiation timing analysis from the Phase 3 PRIME study of ZEJULA (niraparib) as maintenance therapy at the upcoming 2022 International Gynecologic Cancer Society (ICGS) Annual Meeting.
上海、旧金山和马萨诸塞州坎布里奇,9月2022年2月20日(环球通讯社)--再鼎医药-SB(纳斯达克:ZLAB,香港交易所:9688),是一家以患者为中心、创新、商业阶段的全球生物制药公司,该公司将在即将举行的2022年国际妇科癌症学会年会上展示一张海报,其中包含ZEJULA(尼拉帕利布)作为维持疗法的第三阶段主要研究的启动时机分析。
This post-hoc analysis of the PRIME Phase 3 study evaluated adults with newly diagnosed advanced ovarian cancer who responded to first-line platinum-based chemotherapy, and they were randomized to receive niraparib maintenance treatment or placebo within 12 weeks after chemotherapy completion. The results are as follows:
Prime阶段3研究的这项特别后分析评估了对一线铂类化疗有反应的新诊断的晚期卵巢癌成年人,他们被随机分配到化疗完成后12周内接受niraparib维持治疗或安慰剂治疗。结果如下:
- For patients who received niraparib treatment less than 9 weeks after chemotherapy completion, the median progression-free survival (PFS) (95% CI) was measured at 29.4 months with niraparib versus 8.3 months with placebo (HR =0.31; 95% CI, 0.20–0.48).
- For patients who received niraparib at 9 – 12 weeks after chemotherapy completion, the median PFS was 24.7 months with niraparib versus 10.8 months with placebo (HR=0.60; 95% CI, 0.41–0.89).
- The initiation timing of niraparib maintenance treatment had no significant impact on its safety profile.
- 化疗结束后9周内接受尼拉帕利布治疗的患者,其中位无进展生存期(PFS)(95%CI)为29.4个月,安慰剂组为8.3个月(HR=0.31;95%CI为0.20~0.48)。
- 在化疗结束后9-12周接受尼拉帕利布治疗的患者,中位PFS为24.7个月,安慰剂组为10.8个月(HR=0.60;95%CI,0.41-0.89)。
- 尼拉帕利维持治疗的开始时间对其安全性没有显著影响。
This subgroup analysis provides evidence to support the initiation of niraparib maintenance treatment in patients with newly diagnosed advanced ovarian cancer within 12 weeks after chemotherapy completion.
这一亚组分析提供了证据,支持在化疗完成后12周内开始对新诊断的晚期卵巢癌患者进行尼拉帕利维持治疗。
"We are excited to be presenting at the 2022 International Gynecologic Cancer Society Annual Meeting showing these results improved clinical efficacy when niraparib maintenance treatment is initiated within 12 weeks after chemotherapy in patients with advanced ovarian cancer," said Alan Sandler, M.D., President and Head of Global Development, Oncology, Zai Lab. "This study further supports ZEJULA as an important maintenance treatment therapy after platinum-based chemotherapy in people with advanced ovarian cancer."
“我们很高兴能在2022年国际妇科癌症学会年会上展示这些结果,表明当晚期卵巢癌患者在化疗后12周内开始尼拉帕利维持治疗时,这些结果提高了临床疗效,”医学博士艾伦·桑德勒、总裁和肿瘤学全球发展负责人再鼎医药-SB说。这项研究进一步支持ZEJULA作为晚期卵巢癌患者铂类药物化疗后的一种重要的维持治疗方法。“
"This PRIME study analysis will help support clinical practice in treating advanced ovarian cancer in China, showing niraparib extended progression-free survival when maintenance treatment begins within 12 weeks after chemotherapy," said Jing Wang, M.D., Director of the Early Clinical Research Center, Hunan Cancer Hospital. "Since a majority of women face recurrence of advanced ovarian cancer after chemotherapy, this study supports niraparib maintenance treatment having a significant clinical benefit in extending progression-free survival compared to placebo."
湖南肿瘤医院早期临床研究中心董事医学博士王静说:“这项优质研究分析将有助于支持中国治疗晚期卵巢癌的临床实践,表明当化疗后12周内开始维持治疗时,尼拉帕利延长了无进展生存期。”由于大多数妇女在化疗后面临晚期卵巢癌的复发,这项研究支持尼拉帕利维持治疗与安慰剂相比,在延长无进展存活期方面具有显著的临床益处。“
Details regarding the e-poster presentation at IGCS 2022 are as follows:
关于2022年国际政府间气候变化大会电子海报介绍的详情如下:
Abstract number: 876 Title: Impact of initiation timing of niraparib maintenance treatment in newly diagnosed advanced ovarian cancer Speaker: Jing Wang, M.D., Hunan Cancer Hospital Date: September 29-October 1, 2022 |
抽象数: 876 标题尼拉帕利维持治疗开始时机对新诊断晚期卵巢癌的影响 扬声器:王静,医学博士,湖南省肿瘤医院 日期:2022年9月29日-10月1日 |
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moomoo是Moomoo Technologies Inc.公司提供的金融信息和交易应用程序。
在美国,moomoo上的投资产品和服务由Moomoo Financial Inc.提供,一家受美国证券交易委员会(SEC)监管的持牌主体。 Moomoo Financial Inc.是金融业监管局(FINRA)和证券投资者保护公司(SIPC)的成员。
在新加坡,moomoo上的投资产品和服务是通过Moomoo Financial Singapore Pte. Ltd.提供,该公司受新加坡金融管理局(MAS)监管(牌照号码︰CMS101000) ,持有资本市场服务牌照 (CMS) ,持有财务顾问豁免(Exempt Financial Adviser)资质。本内容未经新加坡金融管理局的审查。
在澳大利亚,moomoo上的金融产品和服务是通过Futu Securities (Australia) Ltd提供,该公司是受澳大利亚证券和投资委员会(ASIC)监管的澳大利亚金融服务许可机构(AFSL No. 224663)。请阅读并理解我们的《金融服务指南》、《条款与条件》、《隐私政策》和其他披露文件,这些文件可在我们的网站 https://www.moomoo.com/au中获取。
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