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阿斯利康(AZN.US)TOPAZ-1III期临床研究晚期胆道癌患者OS翻倍

AstraZeneca (AZN.US) TOPAZ-1 III clinical study doubles OS in patients with advanced biliary tract cancer

Zhitong Finance · Apr 17 08:49

AZN -0.43%

4月16日，阿斯利康(AZN.US)公布了3期临床试验TOPAZ-1的最新探索性分析结果。

智通财经APP获悉，4月16日，阿斯利康(AstraZeneca/AZN.US)公布了3期临床试验TOPAZ-1的最新探索性分析结果。数据显示，其重磅免疫疗法Imfinzi与标准化疗联用，在3年时为晚期胆道癌(BTC)患者提供了具有临床意义的长期总生存期(OS)益处。接受Imfinzi组合疗法治疗的患者在三年时的生存率是单独化疗组的两倍以上（14.6%比6.9%）。

Imfinzi是一种人源化单克隆抗体，它与PD-L1蛋白结合并阻断PD-L1与PD-1及CD80蛋白的相互作用，从而对抗肿瘤的免疫逃逸策略，并解除对免疫反应的抑制，增强免疫系统杀伤癌细胞的能力。

On April 16, AstraZeneca (AZN.US) announced the latest exploratory analysis results of the phase 3 clinical trial TOPAZ-1.

The Zhitong Finance App learned that on April 16, AstraZeneca (AstraZeneca/AZN.us) announced the latest exploratory analysis results of the phase 3 clinical trial TOPAZ-1. The data showed that its major immunotherapy Imfinzi in combination with standardized treatment provided clinically significant long-term overall survival (OS) benefits to patients with advanced biliary tract cancer (BTC) at 3 years. The survival rate of patients treated with Imfinzi combination therapy at 3 years was more than double that of the chemotherapy group alone (14.6% compared to 6.9%).

Imfinzi is a humanized monoclonal antibody. It binds to PD-L1 protein and blocks the interaction of PD-L1 with PD-1 and CD80 proteins to fight tumor immune escape strategies, remove suppression of immune responses, and enhance the immune system's ability to kill cancer cells.

Disclaimer: This content is for informational and educational purposes only and does not constitute a recommendation or endorsement of any specific investment or investment strategy. Read more

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This page is machine-translated. Moomoo tries to improve but do not guarantee the accuracy and reliability of the translation, and will not be liable for any loss or damage caused by any inaccuracy or omission of the translation.

This presentation is for informational and educational use only and is not a recommendation or endorsement of any particular investment or investment strategy. Investment information provided in this content is general in nature, strictly for illustrative purposes, and may not be appropriate for all investors. It is provided without respect to individual investors’ financial sophistication, financial situation, investment objectives, investing time horizon, or risk tolerance. You should consider the appropriateness of this information having regard to your relevant personal circumstances before making any investment decisions. Past investment performance does not indicate or guarantee future success. Returns will vary, and all investments carry risks, including loss of principal. Moomoo makes no representation or warranty as to its adequacy, completeness, accuracy or timeline for any particular purpose of the above content.

Moomoo is a financial information and trading app offered by Moomoo Technologies Inc.

In the U.S., investment products and services available through the moomoo app are offered by Moomoo Financial Inc., a broker-dealer registered with the U.S. Securities and Exchange Commission (SEC) and a member of Financial Industry Regulatory Authority (FINRA)/Securities Investor Protection Corporation (SIPC).

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In Australia, financial products and services available through the moomoo app are provided by Futu Securities (Australia) Ltd, an Australian Financial Services Licensee (AFSL No. 224663) regulated by the Australian Securities and Investment Commission (ASIC). Please read and understand our Financial Services Guide, Terms and Conditions, Privacy Policy and other disclosure documents which are available on our website https://www.moomoo.com/au.

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