Gainers

• Siyata Mobile Inc. (NASDAQ:SYTA) rose 41.5% to $0.3255 in pre-market trading after gaining 8% on Tuesday.
• Faraday Future Intelligent Electric Inc. (NASDAQ:FFIE) rose 26.4% to $0.60 in pre-market trading after the company announced strategic agreement with the City of Huanggang and signed a new shareholder agreement with FF Global Partners.
• Celyad Oncology SA (NASDAQ:CYAD) shares rose 26.4% to $2.41 in pre-market trading after jumping 138% on Tuesday. Celyad Oncology recently issued an update on its Celyad 2.0 business strategy, which has been adopted and implemented over the last few months.
• Avenue Therapeutics, Inc. (NASDAQ:ATXI) shares rose 15.1% to $2.29 in pre-market trading after climbing over 60% on Tuesday. Avenue Therapeutics, during November, posted a Q3 loss of $0.45 per share.
• PaxMedica, Inc. (NASDAQ:PXMD) shares rose 14% to $3.34 in pre-market trading after gaining around 17% on Tuesday.
• AVITA Medical, Inc. (NASDAQ:RCEL) rose 12.4% to $9.05 in pre-market trading after gaining around 7% on Tuesday. AVITA Medical, last month, submitted FDA PMA application to expand indication to vitiligo.
• Citius Pharmaceuticals, Inc. (NASDAQ:CTXR) rose 10.6% to $1.25 in pre-market trading. Citius Pharmaceuticals, last month, reported FY22 earnings results.
• Aterian, Inc. (NASDAQ:ATER) rose 9.8% to $1.46 in pre-market trading. Aterian shares gained 37% on Tuesday after the company issued Q4 revenue guidance above analyst estimates.
• Healthcare Triangle, Inc. (NASDAQ:HCTI) rose 8.7% to $0.25 in pre-market trading. Healthcare Triangle, during November, posted a Q3 loss of $0.06 per share.
• Moderna, Inc. (NASDAQ:MRNA) rose 6.5% to $203.00 in pre-market trading after the company's syncytial virus vaccine candidate met its primary endpoint in a Phase 3 trial.

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Losers

• Arcimoto, Inc. (NASDAQ:FUV) fell 44.4% to $3.40 in pre-market trading after the company reported a proposed public offering.
• IronNet, Inc. (NYSE:IRNT) shares fell 11.8% to $0.3601 in pre-market trading. IronNet, last month, announced receipt of noncompliance letter from NYSE.
• The Very Good Food Company Inc. (NASDAQ:VGFC) fell 10.5% to $0.06 in pre-market trading. The Very Good Food Company announced the receivership order, suspension of trading and board member resignation.
• Edesa Biotech, Inc. (NASDAQ:EDSA) fell 8.9% to $1.33 in pre-market trading. Edesa Biotech shares dropped around 42% on Tuesday after the company reported topline Phase 2b results for its dermatology drug.
• Hour Loop, Inc. (NASDAQ:HOUR) shares fell 8.7% to $2.61 in pre-market trading after gaining over 5% on Tuesday.
• SOS Limited (NYSE:SOS) fell 7.7% to $7.56 in pre-market after jumping around 20% on Tuesday.
• BIT Mining Limited (NYSE:BTCM) shares dropped 6.8% to $4.06 in pre-market trading. BIT Mining shares jumped 42% on Tuesday after the company announced the launch of a new energy efficient LiteCoin/DogeCoin Miner, LD3.
• Calyxt, Inc. (NASDAQ:CLXT) fell 6.3% to $0.3310 in pre-market trading. Calyxt shares jumped over 90% on Tuesday after the company and Cibus announced a definitive merger agreement.
• Aptinyx Inc. (NASDAQ:APTX) fell 6.3% to $0.46 in pre-market trading. Aptinyx , during November, posted a Q3 loss of $0.23 per share.
• MultiMetaVerse Holdings Limited (NASDAQ:MMV) fell 5.5% to $2.71 in pre-market trading. MultiMetaVerse recently announced a letter of intent to acquire a majority equity stake in Taomee.