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Adaptimmune Therapeutics Announces Data From Cohort 1 Of SPEARHEAD-1 Trial At CTOS Continue To Support BLA Submission For Afami-cel In Synovial Sarcoma

Benzinga Real-time News ·  Nov 18, 2022 08:04

- Data indicate continued clinical responses with an acceptable safety profile in heavily pre-treated patients with late-stage synovial sarcoma after a single dose of afami-cel -

- Overall response rate in synovial sarcoma of 39% by independent review -consistent with previous data -

-Median duration of response of 50 weeks, consistent with previous data -

- Afami-cel drives tumor infiltration of activated and proliferative cytotoxic ("killer") T-cells into tumors - which likely contributes to antitumor response -

- Adaptimmune is on track to initiate a rolling BLA submission for afami-cel for the treatment of synovial sarcoma in Q4 2022 with a target for completion in mid-year 2023 -

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