U.S. stock futures traded higher this morning on Wednesday. Here are some big stocks recording losses in today's pre-market trading session.

• ARS Pharmaceuticals, Inc. (NASDAQ:SPRY) shares dipped 46.8% to $3.51 in pre-market trading after the FDA issued a Complete Response Letter for ARS Pharma's neffy Epinephrine nasal spray, with request for additional study.
• Revance Therapeutics, Inc. (NASDAQ:RVNC) shares declined 5.8% to $13.01 in pre-market trading. Revance Therapeutics shares fell 17% on Tuesday after the company said it commenced a plan to exit the OPUL payments business and expects to record a restructuring charge of up to $7 million.
• Instacart (Maplebear Inc.) (NASDAQ:CART) shares fell 4.4% to $32.21 in pre-market trading after gaining 12% on Tuesday. Instacart priced its IPO at $30 per share late Monday, which was at the top end of the expected range. Needham initiated coverage on Maplebear with a Hold rating.
• Meta Data Limited (NYSE:AIU) shares fell 4% to $0.96 in pre-market trading after declining around 5% on Tuesday.
• Nikola Corporation (NASDAQ:NKLA) shares declined 3.2% to $1.50 in pre-market trading. Nikola recently announced the appointment of a new chief operating officer.
• Toyota Motor Corporation (NYSE:TM) shares fell 2.6% to $190.06 in pre-market trading after adding 3% on Tuesday.

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