The following is a summary of the Wave Life Sciences Ltd. (WVE) Q1 2024 Earnings Call Transcript:

Financial Performance:

• Wave Life Sciences reported first quarter revenue of $12.5 million, primarily driven by its collaboration with Takeda.

• Research and development expenses increased to $33.4 million, due to increased spending on clinical programs and the Inhibin program.

• Net loss for the quarter increased to $31.6 million, from the previous year's $27.4 million.

• The company ended the quarter with $180.9 million in cash and cash equivalents, and anticipates that these resources will support its operations until Q4 2025.

Business Progress:

• Wave Life Sciences is advancing its three clinical trials: the RestorAATion program for AATD, the FORWARD-53 clinical trial for DMD, and the Select HD trial for Huntington's disease.

• The company also reported progress in its research collaboration with GSK, with the latter selecting the collaboration's first two programs following target validation.

• Dr. Erik Ingelsson joined the company as Chief Scientific Officer, reinforcing the company's scientific leadership.

• Based on advances in the RestorAATion-2 clinical trial, Wave Life Sciences expects to provide proof of mechanism data for WVE-006 later this year.

• The company also anticipates data from clinical trials for DMD and HD in the coming months, underlining the potential of WVE-N531 to restore functional dystrophin for patients with DMD who can skip exon 53.

• The company is on schedule to deliver clinical data for DMD and HD in the forthcoming months.

• Wave Life Sciences plans to initiate a trial for its Inhibin βE program, aimed at treating obesity, in Q1 2025.

• The company is progressing with their RNA editing program WVE-006 for AATD and allele-selective therapeutic WVE-003 for Huntington's disease.

• Wave Life Sciences is exploring potential implications of INHBE Beta E in energy expenditure and improved insulin resistance.

• The company's collaboration with GSK has led to the nomination of two hepatology-targeting programs into GSK's pipeline.

• The company is also preparing to present at the RBC Capital Markets Global Healthcare Conference.

More details: Wave Life Sciences IR

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