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Envisioning A Cocaine-Addiction Treatment: This Next-Gen Psychedelic Shows Positive Results
Envisioning A Cocaine-Addiction Treatment: This Next-Gen Psychedelic Shows Positive Results
Israel-based psychedelics biotech Clearmind Medicine Inc. (NASDAQ:CMND) shared additional positive results on the impact of the MEAI molecule in the natural reward process in an in-vivo preclinical study of cocaine addiction.
"We are thrilled to continuously exhibit positive results of our proprietary drug candidate MEAI. The results of these latest in-vivo studies reinforce previous findings and demonstrate that MEAI may be an effective treatment addiction without negatively affecting natural reward," said CEO Dr. Adi Zuloff-Shani. "Cocaine is extremely addictive and there is currently no dedicated treatment. I believe Clearmind is leading the way in this field."
The research, led by Prof. Gal Yadid at Bar Ilan University was based on the prior finding that Clearmind's proprietary MEAI, at a dose of 5mg per kg, has the ability to decrease cocaine craving and potentially become the first exclusive cocaine addiction treatment.
Reward-based positive reinforcement is a shared evolutionary survival strategy across species, becoming maladaptive and endangering survival in the case of drug addictions. Therefore, the study's aim was to conclude whether MEAI uses the same mechanisms that underlie the seeking of both drug and natural rewards, such as sucrose.
Results demonstrated that natural reward was maintained in the MEAI-treated rats, showing that the effect of MEAI on drug-seeking is not related to the general reward system.
"Very interesting results were revealed in this set of in-vivo studies. The empirical data show that MEAI is a potential treatment for cocaine addiction, in particular, and substance use disorders (SUD), in general. This observation is based on our experience and previous data from testing various treatments for SUD," concluded Prof. Gal Yadid, adding that further studies are needed to better define the responding population.
Additionally, these results are linked to the ongoing collaboration between Clearmind and another specialty pharma company, SciSparc Ltd. (NASDAQ:SPRC). Both firms have partnered for a provisional patent application for the treatment of cocaine addiction with the combination of SciSparc's CannAmide's palmitoylethanolamide and Clearmind's MEAI.
Photo: Benzinga edit
Israel-based psychedelics biotech Clearmind Medicine Inc. (NASDAQ:CMND) shared additional positive results on the impact of the MEAI molecule in the natural reward process in an in-vivo preclinical study of cocaine addiction.
總部位於以色列的迷幻藥物科技 Clearmind 醫學公司(NASDAQ:CMND)在可卡因成癮的體內臨床前研究中,分享了 MEAI 分子在自然獎勵過程中的影響的額外積極結果。
"We are thrilled to continuously exhibit positive results of our proprietary drug candidate MEAI. The results of these latest in-vivo studies reinforce previous findings and demonstrate that MEAI may be an effective treatment addiction without negatively affecting natural reward," said CEO Dr. Adi Zuloff-Shani. "Cocaine is extremely addictive and there is currently no dedicated treatment. I believe Clearmind is leading the way in this field."
「我們很高興能夠持續展現我們專有候選藥物 MEAI 的積極成果。這些最新的體內研究結果強化了先前的發現,並證明 MEAI 可能是一種有效的治療成癮,而不會對自然獎勵產生負面影響。」「可卡因非常容易上癮,目前沒有專門的治療方法。我相信 Clearmind 正在這一領域領先地位。」
The research, led by Prof. Gal Yadid at Bar Ilan University was based on the prior finding that Clearmind's proprietary MEAI, at a dose of 5mg per kg, has the ability to decrease cocaine craving and potentially become the first exclusive cocaine addiction treatment.
由巴爾宜蘭大學 Gal Yadid 教授領導的研究是基於之前發現 Clearmind 的專有 MEAI,劑量為每公斤 5 毫克,具有減少可卡因渴望的能力,並有可能成為第一個獨家可卡因成癮治療的能力。
Reward-based positive reinforcement is a shared evolutionary survival strategy across species, becoming maladaptive and endangering survival in the case of drug addictions. Therefore, the study's aim was to conclude whether MEAI uses the same mechanisms that underlie the seeking of both drug and natural rewards, such as sucrose.
基於獎勵的積極強化是跨物種共享的進化生存策略,在吸毒成癮的情況下變得適應不良並危及生存。因此,該研究的目的是得出結論 MEAI 是否使用與尋求藥物和天然獎勵(例如蔗糖)相同的機制。
Results demonstrated that natural reward was maintained in the MEAI-treated rats, showing that the effect of MEAI on drug-seeking is not related to the general reward system.
研究結果顯示,經過 MEAI 治療的老鼠中維持著自然獎勵,表明 MEAI 對尋毒的影響與一般獎勵制度無關。
"Very interesting results were revealed in this set of in-vivo studies. The empirical data show that MEAI is a potential treatment for cocaine addiction, in particular, and substance use disorders (SUD), in general. This observation is based on our experience and previous data from testing various treatments for SUD," concluded Prof. Gal Yadid, adding that further studies are needed to better define the responding population.
「在這套體內研究中揭示了非常有趣的結果。實證數據顯示 MEAI 一般是可卡因成癮的潛在治療方法,尤其是物質濫用障礙(SUD)。這項觀察基於我們的經驗和測試 SUD 各種治療方法的先前數據。」Gal Yadid 教授總結道,並補充說,需要進一步的研究來更好地定義應對人群。
Additionally, these results are linked to the ongoing collaboration between Clearmind and another specialty pharma company, SciSparc Ltd. (NASDAQ:SPRC). Both firms have partnered for a provisional patent application for the treatment of cocaine addiction with the combination of SciSparc's CannAmide's palmitoylethanolamide and Clearmind's MEAI.
此外,這些結果與 Clearmind 和另一家專業製藥公司之間的持續合作有關,SciSprc 有限公司(NASDAQ:SPRC)。這兩家公司已經合作,用於治療可卡因成癮的臨時專利申請與 SciSparc 的 Cannamide 的棕櫚酰胺和 Clearmind 的 MEAI 相結合。
Photo: Benzinga edit
照片:汽油編輯
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moomoo是Moomoo Technologies Inc.公司提供的金融資訊和交易應用程式。
在美國,moomoo上的投資產品和服務由Moomoo Financial Inc.提供,一家受美國證券交易委員會(SEC)監管的持牌主體。 Moomoo Financial Inc.是金融業監管局(FINRA)和證券投資者保護公司(SIPC)的成員。
在新加坡,moomoo上的投資產品和服務是通過Moomoo Financial Singapore Pte. Ltd.提供,該公司受新加坡金融管理局(MAS)監管(牌照號碼︰CMS101000) ,持有資本市場服務牌照 (CMS) ,持有財務顧問豁免(Exempt Financial Adviser)資質。本內容未經新加坡金融管理局的審查。
在澳大利亞,moomoo上的金融產品和服務是通過Futu Securities (Australia) Ltd提供,該公司是受澳大利亞證券和投資委員會(ASIC)監管的澳大利亞金融服務許可機構(AFSL No. 224663)。請閱讀並理解我們的《金融服務指南》、《條款與條件》、《隱私政策》和其他披露文件,這些文件可在我們的網站 https://www.moomoo.com/au中獲取。
在加拿大,透過moomoo應用程式提供的僅限訂單執行的券商服務由Moomoo Financial Canada Inc.提供,並受加拿大投資監管機構(CIRO)監管。
在馬來西亞,moomoo上的投資產品和服務是透過Moomoo Securities Malaysia Sdn. Bhd. 提供,該公司受馬來西亞證券監督委員會(SC)監管(牌照號碼︰eCMSL/A0397/2024) ,持有資本市場服務牌照 (CMSL) 。本內容未經馬來西亞證券監督委員會的審查。
Moomoo Technologies Inc., Moomoo Financial Inc., Moomoo Financial Singapore Pte. Ltd.,Futu Securities (Australia) Ltd, Moomoo Financial Canada Inc和Moomoo Securities Malaysia Sdn. Bhd., 是關聯公司。
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