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Envisioning A Cocaine-Addiction Treatment: This Next-Gen Psychedelic Shows Positive Results
Envisioning A Cocaine-Addiction Treatment: This Next-Gen Psychedelic Shows Positive Results
Israel-based psychedelics biotech Clearmind Medicine Inc. (NASDAQ:CMND) shared additional positive results on the impact of the MEAI molecule in the natural reward process in an in-vivo preclinical study of cocaine addiction.
"We are thrilled to continuously exhibit positive results of our proprietary drug candidate MEAI. The results of these latest in-vivo studies reinforce previous findings and demonstrate that MEAI may be an effective treatment addiction without negatively affecting natural reward," said CEO Dr. Adi Zuloff-Shani. "Cocaine is extremely addictive and there is currently no dedicated treatment. I believe Clearmind is leading the way in this field."
The research, led by Prof. Gal Yadid at Bar Ilan University was based on the prior finding that Clearmind's proprietary MEAI, at a dose of 5mg per kg, has the ability to decrease cocaine craving and potentially become the first exclusive cocaine addiction treatment.
Reward-based positive reinforcement is a shared evolutionary survival strategy across species, becoming maladaptive and endangering survival in the case of drug addictions. Therefore, the study's aim was to conclude whether MEAI uses the same mechanisms that underlie the seeking of both drug and natural rewards, such as sucrose.
Results demonstrated that natural reward was maintained in the MEAI-treated rats, showing that the effect of MEAI on drug-seeking is not related to the general reward system.
"Very interesting results were revealed in this set of in-vivo studies. The empirical data show that MEAI is a potential treatment for cocaine addiction, in particular, and substance use disorders (SUD), in general. This observation is based on our experience and previous data from testing various treatments for SUD," concluded Prof. Gal Yadid, adding that further studies are needed to better define the responding population.
Additionally, these results are linked to the ongoing collaboration between Clearmind and another specialty pharma company, SciSparc Ltd. (NASDAQ:SPRC). Both firms have partnered for a provisional patent application for the treatment of cocaine addiction with the combination of SciSparc's CannAmide's palmitoylethanolamide and Clearmind's MEAI.
Photo: Benzinga edit
Israel-based psychedelics biotech Clearmind Medicine Inc. (NASDAQ:CMND) shared additional positive results on the impact of the MEAI molecule in the natural reward process in an in-vivo preclinical study of cocaine addiction.
总部位于以色列的迷幻生物技术公司Clearmind Medicine Inc.(纳斯达克股票代码:CMND)在一项针对可卡因成瘾的体内临床前研究中分享了关于MEAI分子在自然奖励过程中的影响的其他积极结果。
"We are thrilled to continuously exhibit positive results of our proprietary drug candidate MEAI. The results of these latest in-vivo studies reinforce previous findings and demonstrate that MEAI may be an effective treatment addiction without negatively affecting natural reward," said CEO Dr. Adi Zuloff-Shani. "Cocaine is extremely addictive and there is currently no dedicated treatment. I believe Clearmind is leading the way in this field."
“我们很高兴能持续展示我们的专有候选药物MEAI的积极结果。这些最新的体内研究结果强化了先前的发现,并表明MEAI可能是一种有效的治疗成瘾,不会对自然奖励产生负面影响。” 首席执行官阿迪·祖洛夫-沙尼博士说。“可卡因极易上瘾,目前没有专门的治疗方法。我相信 Clearmind 在这一领域处于领先地位。”
The research, led by Prof. Gal Yadid at Bar Ilan University was based on the prior finding that Clearmind's proprietary MEAI, at a dose of 5mg per kg, has the ability to decrease cocaine craving and potentially become the first exclusive cocaine addiction treatment.
这项研究由巴伊兰大学的加尔·亚迪德教授领导,其基础是先前的发现,即Clearmind的专有MEAI每千克剂量为5mg,能够减少对可卡因的渴望,并有可能成为第一种独家可卡因成瘾疗法。
Reward-based positive reinforcement is a shared evolutionary survival strategy across species, becoming maladaptive and endangering survival in the case of drug addictions. Therefore, the study's aim was to conclude whether MEAI uses the same mechanisms that underlie the seeking of both drug and natural rewards, such as sucrose.
基于奖励的积极强化是跨物种共同的进化生存策略,在吸毒成瘾的情况下会变得适应不良并危及生存。因此,该研究的目的是得出结论,MEAI使用的机制是否与寻求药物和自然奖励(例如蔗糖)的基础相同。
Results demonstrated that natural reward was maintained in the MEAI-treated rats, showing that the effect of MEAI on drug-seeking is not related to the general reward system.
结果表明,接受MEAI治疗的大鼠的自然奖励得以维持,这表明MEAI对药物寻求的影响与一般奖励系统无关。
"Very interesting results were revealed in this set of in-vivo studies. The empirical data show that MEAI is a potential treatment for cocaine addiction, in particular, and substance use disorders (SUD), in general. This observation is based on our experience and previous data from testing various treatments for SUD," concluded Prof. Gal Yadid, adding that further studies are needed to better define the responding population.
“这组体内研究揭示了非常有趣的结果。实证数据表明,MEAI是治疗可卡因成瘾的潜在方法,尤其是药物滥用障碍(SUD)的潜在治疗方法。这一观察结果基于我们的经验和先前测试各种SUD疗法的数据。” 加尔·亚迪德教授总结道,并补充说,要更好地定义反应人群,还需要进一步研究。
Additionally, these results are linked to the ongoing collaboration between Clearmind and another specialty pharma company, SciSparc Ltd. (NASDAQ:SPRC). Both firms have partnered for a provisional patent application for the treatment of cocaine addiction with the combination of SciSparc's CannAmide's palmitoylethanolamide and Clearmind's MEAI.
此外,这些结果与Clearmind与另一家专业制药公司SciSparc Ltd.(纳斯达克股票代码:SPRC)之间的持续合作有关。两家公司已合作申请了治疗可卡因成瘾的临时专利,该专利将sciSparc的Cannamide的棕榈酰乙醇胺和Clearmind的MEAI相结合。
Photo: Benzinga edit
照片:Benzinga 编辑
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moomoo是Moomoo Technologies Inc.公司提供的金融信息和交易应用程序。
在美国,moomoo上的投资产品和服务由Moomoo Financial Inc.提供,一家受美国证券交易委员会(SEC)监管的持牌主体。 Moomoo Financial Inc.是金融业监管局(FINRA)和证券投资者保护公司(SIPC)的成员。
在新加坡,moomoo上的投资产品和服务是通过Moomoo Financial Singapore Pte. Ltd.提供,该公司受新加坡金融管理局(MAS)监管(牌照号码︰CMS101000) ,持有资本市场服务牌照 (CMS) ,持有财务顾问豁免(Exempt Financial Adviser)资质。本内容未经新加坡金融管理局的审查。
在澳大利亚,moomoo上的金融产品和服务是通过Futu Securities (Australia) Ltd提供,该公司是受澳大利亚证券和投资委员会(ASIC)监管的澳大利亚金融服务许可机构(AFSL No. 224663)。请阅读并理解我们的《金融服务指南》、《条款与条件》、《隐私政策》和其他披露文件,这些文件可在我们的网站 https://www.moomoo.com/au中获取。
在加拿大,通过moomoo应用提供的仅限订单执行的券商服务由Moomoo Financial Canada Inc.提供,并受加拿大投资监管机构(CIRO)监管。
在马来西亚,moomoo上的投资产品和服务是通过Moomoo Securities Malaysia Sdn. Bhd. 提供,该公司受马来西亚证券监督委员会(SC)监管(牌照号码︰eCMSL/A0397/2024) ,持有资本市场服务牌照 (CMSL) 。本内容未经马来西亚证券监督委员会的审查。
Moomoo Technologies Inc., Moomoo Financial Inc., Moomoo Financial Singapore Pte. Ltd., Futu Securities (Australia) Ltd, Moomoo Financial Canada Inc.,和Moomoo Securities Malaysia Sdn. Bhd.是关联公司。
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