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Affivant to Present Data on AFVT-2101 at 37th Annual Meeting of SITC
Affivant to Present Data on AFVT-2101 at 37th Annual Meeting of SITC
NEW YORK and BASEL, Switzerland, Nov. 10, 2022 (GLOBE NEWSWIRE) -- Affivant, a biotechnology company dedicated to developing novel immune-oncology approaches to activate and enable the innate immune system to fight cancer, will present a poster at the 37th Annual Meeting of The Society for Immunotherapy of Cancer (SITC) highlighting preclinical data for AFVT-2101 (previously AFM32).
AFVT-2101 is a tetravalent, bispecific Innate Cell Engager (ICE®) that bridges folate receptor alpha (FRα) on tumor cells with CD16A expressing innate immune cells, to induce potent and selective targeted tumor cell killing. FRα is a tumor-associated antigen which is highly overexpressed on a variety of epithelial tumors.
The following poster will be presented live at SITC on November 11th:
Title: AFVT-2101, an innate immune-cell engager that selectively targets FOLR1 expressing tumor cells to safely harness potent anti-cancer responses
Poster #: 1212
Authors: Ahmad Trad, Michael Tomaszowski, Josef Caslavsky, Robert Freitag, Sudhir Penugonda, Keith Haan, Markus Rohrwild, Daniel O'Shannessy, Jana Siegler, Peter Sandy, Eric Gaukel, Daniela Penston, Zoë Johnson
The poster shows that AFVT-2101 binds selectively to CD16A (both 158V and 158F variants). Physiological levels of competing IgG do not alter binding efficacy. AFVT-2101 induces potent and selective ADCC, even on FRα low expressing cell lines. AFVT-2101 is also shown to induce efficient ADCP in vitro. Co-culture of PBMCs, tumor cells and AFVT-2101 showed concentration-dependent release of pro-inflammatory cytokines (IFNγ, IP-10, TNFα) and minimal off-target cytokine release, confirming a potent but safe in vitro profile of AFVT-2101.
About ICE molecules
Innate Cell Engager (ICE®) molecules are designed to bivalently bind CD16A+ cells of the innate immune system and a tumor associated antigen, inducing potent, tumor-directed cytotoxicity via antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP).
About Affivant
Affivant, a Roivant Sciences company, is dedicated to developing novel immune-oncology approaches to activate and enable the innate immune system to fight cancer. Our innovative bi-specific innate cell engagers are designed to target specific patient populations as powerful monotherapies and combination treatments. AFVT-2101 is currently in IND-enabling studies.
For more information, visit .
Contact:
Zoë Johnson, Chief Scientific Officer
zoe.johnson@affivant.com
NEW YORK and BASEL, Switzerland, Nov. 10, 2022 (GLOBE NEWSWIRE) -- Affivant, a biotechnology company dedicated to developing novel immune-oncology approaches to activate and enable the innate immune system to fight cancer, will present a poster at the 37th Annual Meeting of The Society for Immunotherapy of Cancer (SITC) highlighting preclinical data for AFVT-2101 (previously AFM32).
纽约和瑞士巴塞尔,2022年11月10日(Global Newswire)--致力于开发新的免疫肿瘤学方法以激活并使先天免疫系统抗击癌症的生物技术公司Affivant将在37这是癌症免疫治疗学会(SITC)年度会议,重点介绍AFVT-2101(以前的AFM32)的临床前数据。
AFVT-2101 is a tetravalent, bispecific Innate Cell Engager (ICE®) that bridges folate receptor alpha (FRα) on tumor cells with CD16A expressing innate immune cells, to induce potent and selective targeted tumor cell killing. FRα is a tumor-associated antigen which is highly overexpressed on a variety of epithelial tumors.
AfVT-2101是一种四价、双特异性的天然细胞激活剂(ICE®),将肿瘤细胞上的叶酸受体α(FRα)与表达CD16A的天然免疫细胞连接起来,诱导有效和选择性的靶向肿瘤细胞杀伤。FRα是一种肿瘤相关抗原,在多种上皮性肿瘤中高表达。
The following poster will be presented live at SITC on November 11th:
以下海报将于11月11日在SITC现场展示这是:
Title: AFVT-2101, an innate immune-cell engager that selectively targets FOLR1 expressing tumor cells to safely harness potent anti-cancer responses
标题:AfVT-2101,一种先天免疫细胞激活剂,选择性靶向表达FOLR1的肿瘤细胞,以安全地利用强大的抗癌反应
Poster #: 1212
发信人:1212
Authors: Ahmad Trad, Michael Tomaszowski, Josef Caslavsky, Robert Freitag, Sudhir Penugonda, Keith Haan, Markus Rohrwild, Daniel O'Shannessy, Jana Siegler, Peter Sandy, Eric Gaukel, Daniela Penston, Zoë Johnson
作者:艾哈迈德·特拉德,迈克尔·托马佐夫斯基,约瑟夫·卡斯拉夫斯基,罗伯特·弗雷塔格,苏迪尔·佩努贡达,基思·汉,马库斯·罗威尔德,Daniel·奥尚尼斯,贾娜·西格勒,彼得·桑迪,埃里克·高克尔,丹妮拉·彭斯顿,佐伊·约翰逊
The poster shows that AFVT-2101 binds selectively to CD16A (both 158V and 158F variants). Physiological levels of competing IgG do not alter binding efficacy. AFVT-2101 induces potent and selective ADCC, even on FRα low expressing cell lines. AFVT-2101 is also shown to induce efficient ADCP in vitro. Co-culture of PBMCs, tumor cells and AFVT-2101 showed concentration-dependent release of pro-inflammatory cytokines (IFNγ, IP-10, TNFα) and minimal off-target cytokine release, confirming a potent but safe in vitro profile of AFVT-2101.
海报显示,AFVT-2101选择性地与CD16A(158V和158F变种)结合。竞争的免疫球蛋白的生理水平不会改变结合效率。即使在FRα低表达的细胞系中,AfVT2101也能诱导出强大的、选择性的ADCC。AfVT-2101也被证明可以诱导有效的ADCP体外培养。PBMC、肿瘤细胞和AFVT2101的共培养显示出浓度依赖的促炎细胞因子(干扰素γ、IP-10、肿瘤坏死因子α)的释放和最小的非靶向细胞因子的释放,证实了一种有效但安全的体外培养AFVT-2101的概况。
About ICE molecules
关于冰分子
Innate Cell Engager (ICE®) molecules are designed to bivalently bind CD16A+ cells of the innate immune system and a tumor associated antigen, inducing potent, tumor-directed cytotoxicity via antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP).
先天细胞激活者(ICE®)分子被设计成二价结合先天免疫系统的CD16A+细胞和肿瘤相关抗原,通过抗体依赖的细胞毒性(ADCC)和抗体依赖的细胞吞噬作用(ADCP)诱导强大的肿瘤导向的细胞毒作用。
About Affivant
关于阿菲凡特
Affivant, a Roivant Sciences company, is dedicated to developing novel immune-oncology approaches to activate and enable the innate immune system to fight cancer. Our innovative bi-specific innate cell engagers are designed to target specific patient populations as powerful monotherapies and combination treatments. AFVT-2101 is currently in IND-enabling studies.
Affivant是Roivant Sciences的一家公司,致力于开发新的免疫肿瘤学方法,以激活并使先天免疫系统能够抗击癌症。我们创新的双特定天然细胞活跃器旨在针对特定的患者群体,作为强大的单一疗法和联合疗法。AfVT-2101目前正在进行启用IND的研究。
For more information, visit .
有关更多信息,请访问。
Contact:
联系方式:
Zoë Johnson, Chief Scientific Officer
zoe.johnson@affivant.com
首席科学官佐伊·约翰逊
邮箱:zoe.johnson@affivant.com
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在新加坡,moomoo上的投资产品和服务是通过Moomoo Financial Singapore Pte. Ltd.提供,该公司受新加坡金融管理局(MAS)监管(牌照号码︰CMS101000) ,持有资本市场服务牌照 (CMS) ,持有财务顾问豁免(Exempt Financial Adviser)资质。本内容未经新加坡金融管理局的审查。
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