Gainers

• AeroClean Technologies, Inc. (NASDAQ:AERC) shares gained 689.4% to settle at $78.94 on Wednesday after the company priced its IPO at $10 per share.
• Longeveron Inc. (NASDAQ:LGVN) rose 145.6% to settle at $42.30 on Wednesday after tumbling 39% on Tuesday. The company last week announced the FDA granted Rare Pediatric Disease designation for Lomecel-B for the treatment of Hypoplastic Left Heart Syndrome.
• Biofrontera Inc. (NASDAQ:BFRI) shares climbed 98.5% to close $5.22 on Wednesday after Roth Capital initiated coverage on the stock with a Buy rating and a $20 price target.
• IM Cannabis Corp. (NASDAQ:IMCC) gained 37.8% to settle at $4.30. IM Cannabis recently announced its unaudited financial results on Monday for the three and nine-month periods ended September 30, 2021, with revenues of CA$14.4 million ($11.5 million), a sequential increase of approximately 30%.
• Local Bounti Corporation (NYSE:LOCL) surged 32.6% to close at $10.62.
• Blue Star Foods Corp. (NASDAQ:BSFC) gained 29.9% to settle at $3.65. Blue Star Foods recently reported $3.73 million in quarterly sales.
• Spark Networks SE (NYSE:LOV) jumped 23.6% to close at $3.30. Spark Networks 10% owner Osmium Diamond Lp acquired a total of 1654197 shares at an average price of $2.51.
• Femasys Inc. (NASDAQ:FEMY) gained 22.9% to settle at $4.99. Femasys recently posted Q3 loss of $0.19 per share.
• Standard Lithium Ltd. (NYSE:SLI) surged 22.2% to close at $10.63 after the company announced a $100 million direct investment from Koch Strategic Platforms.
• Cyclerion Therapeutics, Inc. (NASDAQ:CYCN) gained 22.1% to settle at $2.65.
• Trio-Tech International (NYSE:TRT) jumped 21.5% to close at $10.75.
• Trio-Tech recently reported Q1 results, posting a 49% year-over-year increase in total revenue.
• Grom Social Enterprises, Inc. (NASDAQ:GROM) rose 20.9% to close at $2.72. Grom Social Enterprises disclosed that its newest division, Curiosity Ink Media, unwrapped Santa.com.
• Dermata Therapeutics, Inc. (NASDAQ:DRMA) gained 20.6% to settle at $2.81. Dermata Therapeutics recently announced data from its Phase 1b proof of concept study evaluating a single treatment of DMT410 to treat multiple aesthetic skin conditions.
• Engine Gaming and Media, Inc. (NASDAQ:GAME) rose 19.8% to close at $3.81 after the company reported Q4 2021 and FY21 revenue was higher year over year.
• IDW Media Holdings, Inc. (NYSE:IDW) gained 19.3% to close at $2.60.
• Better Therapeutics, Inc. (NASDAQ:BTTX) shares rose 19.1% to close at $7.68 after Chardan Capital initiated coverage on the stock with a Buy rating and a $17 price target.
• Augmedix, Inc. (NASDAQ:AUGX) gained 19% to settle at $3.45. Augmedix recently posted a Q3 net loss of $2.859 million.
• Ocuphire Pharma, Inc. (NASDAQ:OCUP) gained 18.8% to close at $4.1350 after the company announced that the first subjects have been enrolled in the MIRA-3 Phase 3 pivotal trial evaluating Nyxol Eye Drops in the reversal of pharmacologically-induced mydriasis.
• Society Pass Incorporated (NASDAQ:SOPA) jumped 17.8% to settle at $13.17 amid continued volatility following the stock's IPO earlier in the month.
• ForgeRock, Inc. (NYSE:FORG) gained 17.6% to close at $29.14. The company recently posted upbeat quarterly results.
• MyMD Pharmaceuticals, Inc. (NASDAQ:MYMD) gained 17.2% to close at $7.10. MyMD Pharma Form 4 filing showed the company’s VP of Operations Paul Rivard bought 15,000 shares of co. stock on Nov. 23.
• Nxt-ID, Inc. (NASDAQ:NXTD) gained 17% to close at $3.10.
• Rani Therapeutics Holdings, Inc. (NASDAQ:RANI) jumped 16.9% to settle at $31.50.
• Finch Therapeutics Group, Inc. (NASDAQ:FNCH) gained 16.3% to close at $15.74. Finch Therapeutics Group recently announced positive topline results from PRISM-EXT, an open-label extension of the PRISM3 Phase 2 trial evaluating CP101 to prevent recurrent C. difficile infection (CDI).
• Global-e Online Ltd. (NASDAQ:GLBE) jumped 15.8% to close at $60.99 after the company announced it will acquire Flow Commerce for an aggregate purchase price of up to approximately $500 million.
• Paltalk, Inc. (NASDAQ:PALT) gained 15.7% to close at $4.06.
• Recursion Pharmaceuticals, Inc. (NASDAQ:RXRX) jumped 15.6% to close at $18.80.
• Recursion Pharmaceuticals recently reported Q3 earnings results.
• Brainstorm Cell Therapeutics Inc. (NASDAQ:BCLI) gained 15.5% to close at $3.43. Brainstorm Cell recently posted Q3 loss of $0.15 per share.
• Guardant Health, Inc. (NASDAQ:GH) gained 15.5% to close at $107.25 following stock purchases by the company's Co-CEOs.
• Instil Bio, Inc. (NASDAQ:TIL) gained 14.5% to settle at $19.86
• Golden Ocean Group Limited (NASDAQ:GOGL) rose 14.1% to close at $9.12 after reporting Q3 results.
• Foghorn Therapeutics Inc. (NASDAQ:FHTX) gained 14.1% to close at $14.21. HC Wainwright & Co. recently initiated coverage on Foghorn Therapeutics with a Buy rating and announced a price target of $25.
• Pure Storage, Inc. (NASDAQ:PSTG) climbed 13.5% to settle at $30.95 after the company reported better-than-expected Q3 EPS and sales results and issued Q4 and FY22 sales guidance above estimates.
• Reviva Pharmaceuticals Holdings, Inc. (NASDAQ:RVPH) gained 13.2% to close at $3.85. Reviva Pharmaceuticals recently posted a Q3 loss of $0.12 per share.
• BIOLASE, Inc. (NASDAQ:BIOL) rose 11.9% to settle at $0.4700 after Nasdaq granted the company 180-day extension to meet minimum bid price requirement. The company also entered into favorable credit deal.
• Guess', Inc. (NYSE:GES) gained 11.4% to close at $23.73 after the company reported better-than-expected Q3 EPS and sales results and raised its quarterly dividend.
• Benessere Capital Acquisition Corp. (NASDAQ:BENE) climbed 10.4% to close at $11.23. eCombustible Energy will merge with Benessere Capital Acquisition Corp. in a $805 million deal.
• Kidpik Corp. (NASDAQ:PIK) gained 10.3% to close at $6.32. The company recently priced its IPO at $8.50 per share.
• HP Inc. (NYSE:HPQ) climbed 10.1% to settle at $35.44 after the company reported better-than-expected results for its fourth quarter and issued strong earnings forecast for the current quarter.
• Bridgeline Digital, Inc. (NASDAQ:BLIN) rose 9.4% to close at $3.04.
• Meiwu Technology Company Limited (NASDAQ:WNW) shares rose 8.3% to close at $3.38.

Check out these big penny stock gainers and losers

Losers

• Qualigen Therapeutics, Inc. (NASDAQ:QLGN) shares fell 31.6% to settle at $1.75 on Wednesday after jumping around 105% on Tuesday.
• Aptevo Therapeutics Inc. (NASDAQ:APVO) fell 29.8% to close at $11.95. Aptevo Therapeutics shares climbed 163% on Tuesday after the company announced a clinical update for its Phase 1b Expansion trial evaluating APVO436 in the treatment of AML. Preliminary data observed to date includes one complete remission.
• Nordstrom, Inc. (NYSE:JWN) shares fell 29% to close at $22.66 after the company reported worse-than-expected Q3 sales results. Jefferies downgraded Nordstrom from Buy to Hold and lowered the price target from $48 to $30.
• Pasithea Therapeutics Corp. (NASDAQ:KTTA) declined 28.8% to close at $3.99. Pasithea Therapeutics priced its 8.68 million share private placement at $3.50 per share.
• Vallon Pharmaceuticals, Inc. (NASDAQ:VLON) fell 26.2% to close at $5.39 on Wednesday after jumping over 80% on Tuesday.
• The Gap, Inc. (NYSE:GPS) fell 24.1% to close at $17.84 after the company reported worse-than-expected Q3 EPS and sales results and cut FY21 adjusted EPS guidance below estimates.
• Esperion Therapeutics, Inc. (NASDAQ:ESPR) shares fell 23.3% to close at $7.69 after surging over 40% on Tuesday.
• iSpecimen Inc. (NASDAQ:ISPC) fell 22.7% to close at $10.20. iSpecimen shares jumped over 48% on Tuesday on continued upward momentum after the company announced it has been contracted to support new advanced research on COVID-19 seeking insights on its transmissibility, variants, outcomes, and testing validity among multiple population segments.
• Petros Pharmaceuticals, Inc. (NASDAQ:PTPI) fell 21.8% to close at $1.83 after jumping over 75% on Tuesday.
• Centogene N.V. (NASDAQ:CNTG) fell 19.2% to close at $7.20. Centogene reported Q3 sales of €30.2 million, down 17% Y/Y, driven by decreasing revenues from COVID-19 testing.
• MediciNova, Inc. (NASDAQ:MNOV) shares fell 19.2% to close at $3.57 after surging 44% on Tuesday.
• Outlook Therapeutics, Inc. (NASDAQ:OTLK) fell 18.6% to close at $1.27 after the company reported a $10 million bought deal offering of common stock.
• TDCX Inc. (NYSE:TDCX) dropped 17.3% to close at $18.72 following Q3 results.
• Nuvation Bio Inc. (NYSE:NUVB) fell 16.2% to close at $7.75.
• Kura Oncology, Inc. (NASDAQ:KURA) declined 15.5% to close at $14.02 after the company announced the FDA placed the KOMET-001 Phase 1b study of KO-539 in patients with relapsed or refractory acute myeloid leukemia (AML) on a partial clinical hold.
• Autodesk, Inc. (NASDAQ:ADSK) shares fell 15.5% to close at $256.90. Autodesk reported upbeat results for its third quarter, but issued disappointing guidance. Autodesk said it sees Q4 revenue of $1.185 billion to $1.2 billion and non-GAAP earnings of $1.41 to $1.47 per share.
• Anaplan, Inc. (NYSE:PLAN) shares fell 15.1% to close at $44.22 after the company reported Q3 earnings results. Piper Sandler downgraded Anaplan from Overweight to Neutral and lowered the price target from $77 to $48.
• Viomi Technology Co., Ltd (NASDAQ:VIOT) slipped 14% to close at $3.51 following Q3 results.
• Eliem Therapeutics, Inc. (NASDAQ:ELYM) declined 12.3% to settle at $15.48
• Clarus Therapeutics Holdings, Inc. (NASDAQ:CRXT) shares fell 12% to close at $5.05. Clarus Therapeutics shares jumped 43% on Tuesday after the company was granted a U.S. Patent titled 'Oral testosterone ester formulations and methods of treating testosterone deficiency comprising same.'
• Noah Holdings Limited (NYSE:NOAH) dropped 11.4% to close at $39.03 following Q3 results. JP Morgan downgraded Noah Holdings from Overweight to Neutral and announced a $50 price target.
• NerdWallet, Inc. (NASDAQ:NRDS) dropped 11.2% to close at $22.59. The company recently priced its IPO at $4 per share.
• Gracell Biotechnologies Inc. (NASDAQ:GRCL) fell 9% to close at $7.09. Gracell Biotechnologies shares gained 22% on Tuesday after the company reported members of its senior management team intend to use personal funds to buy up to $2 million in company ADSs in the open market over the next 3 months.
• Titan Machinery Inc. (NASDAQ:TITN) declined 8.8% to settle at $34.94. Baird downgraded Titan Machinery from Outperform to Neutral and raised the price target from $37 to $41.
• Dillard's, Inc. (NYSE:DDS) fell 7.9% to close at $377.67.
• Citi Trends, Inc. (NASDAQ:CTRN) declined 7.9% to settle at $84.01
• Abercrombie & Fitch Co. (NYSE:ANF) fell 4.6% to close at $39.25. Abercrombie & Fitch recently reported third-quarter FY21 sales growth of 10% year-on-year, to $905.16 million, beating the analyst consensus of $896.86 million.