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$Gritstone Bio(GRTS.US$ Gritstone bio Presents Improvements to EDGE™ Platform at AACR 2024 27 MINUTES AGO, 7:00 AM EDT VIA GLOBENEWSWIRE -- State-of-the-art neoantigen prediction platform (EDGE™) now predicts HLA Class I presentation of epitopes with >80% accuracy -- -- Newly developed EDGE-II model achieves superior predictive performance of HLA Class II presentation and CD4+ immunogenicity over publicly available models -- -- Combined with Gritstone's vaccine vectors, EDGE has demonstrated best-in-class potential in identifying neoantigens capable of eliciting T cell immune responses for robust and durable immunity -- EMERYVILLE, Calif., April 08, 2024 (GLOBE NEWSWIRE) -- Gritstone bio, Inc. (NASDAQ:GRTS), a clinical-stage biotechnology company working to develop the world's most potent vaccines, today presented an update on its T cell epitope discovery platform, EDGE, at the 2024 American Association for Cancer Research (AACR) Annual Meeting in San Diego, CA. The presentation details improvements Gritstone has made in prediction of peptide presentation by HLA Class I, associated with CD8+ T cells, since the publication of the initial results in 2018 (Nature Biotechnology). It also reviews how Gritstone has expanded EDGE's application to predict peptide presentation by HLA Class II. "Identifying which of the hundreds of tumor mutations are most likely to serve as neoantigens, key targets of tumor-specific T cells, is critical to the development of effective neoantigen-directed vaccines," said Andrew Allen, M.D., Ph.D., Co-founder, President, and Chief Executive Officer of Gritstone bio. "Since our Nature Biotechnology publication in 2018, we have further enhanced and expanded the application of EDGE in support of our cancer and infectious disease vaccines by improving our already-robust prediction of HLA Class I epitopes, associated with CD8+ T cell induction, and incorporating HLA Class II epitope prediction to enable CD4+ T cells to join the fight. Gritstone remains at the forefront of driving robust and broad T cell induction post-vaccination, and EDGE is an important asset and differentiator in that effort." "Today, EDGE is able to predict HLA Class I presentation of epitopes with >80% accuracy, a significant increase since 2018 when we initially published the model," said Karin Jooss, Ph.D., Executive Vice President, and Head of R&D of Gritstone bio. "EDGE also now includes a comprehensive state-of-the-art model for predicting peptide presentation by HLA Class II in the context of active vaccination, which could serve to effectively broaden T cell response to our novel vaccines. The improvements we are making to EDGE, leveraging advances in protein large language models and in-house immunopeptidomics, have positioned EDGE as a leading HLA/peptide predictive platform in the neoantigen cancer vaccine field. The superior performance and association with cellular immunity seen across all our models compared to currently publicly available models support Gritstone's potential to develop highly potent vaccines for both oncology and infectious disease."
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