Today's pre-market stock movers: CLVS, PATH, DARE and more

• $Clovis Oncology(CLVS.US)$ +40.6% (Rubraca significantly improves progression-free survival in first-line maintenance treatment in women with ovarian cancer regardless of their biomarker status in phase 3 athena-mono trial)

• $Dare Bioscience(DARE.US)$ +13.61% (Organon and Dar Bioscience have entered into an agreement whereby Organon will license global rights to XACIATO)

• $KULR Technology(KULR.US)$ +9.5% (secured a battery safety contract with NASA to test its lithium-ion cells going into future battery packs designed for the Artemis Program)

• $Vipshop(VIPS.US)$ +6.62% (authorizes $1 bln share repurchase program over the next 24-month period)

• $Mainz Biomed(MYNZ.US)$ +6.8% (completes successful pre-submission process with the FDA for ColoAlert's Pivotal Clinical Trial)

• $PROG Holdings(PRG.US)$ +6% (to move to S&P Small Cap 600 from S&P MidCap 400)

• $Orion SA(OEC.US)$ +4.9% (to raise rubber carbon black prices in Europe)

• $Weibo(WB.US)$ +4% (approves share repurchase of up to $500 mln ADS)

• $Corcept Therapeutics(CORT.US)$ +3.4% (presents results from Phase 2 study of relacorilant plus nab-paclitaxel)

• $Core & Main(CNM.US)$ +2.8% (upgraded to Overweight from Equal Weight at Barclays)

• $Five Below(FIVE.US)$ +2.4% (upgraded to Buy from Neutral at Citigroup)

• $CDW Corp(CDW.US)$ +1.9% (upgraded to Overweight from Equal-Weight at Morgan Stanley)

• $UiPath(PATH.US)$ -19.11%, $Expensify(EXFY.US)$ -9.0%, $Masimo(MASI.US)$ -9.4%, $Phreesia(PHR.US)$ -9.12%, $Sharecare(SHCR.US)$ -16.06%, $Tempur Sealy International(TPX.US)$ -6.04%.

• $iQIYI(IQ.US)$ -10.9% $Hutchmed (China)(HCM.US)$ -1.3% $JD.com(JD.US)$ -2.4% $Baidu(BIDU.US)$ -2.4%

• $Fiesta Restaurant(FRGI.US)$ -7.4% (to be removed from S&.P SmallCap 600)

• $Amylyx Pharmaceuticals(AMLX.US)$ -22.9% (FDA advisory committee votes 6-4 for "no" on effectiveness of AMX0035 for the treatment of ALS)

• $Modiv Industrial(MDV.US)$ -5.5% (files for $200 mln mixed securities shelf offering)

• $Bolt Biotherapeutics(BOLT.US)$ -2.5% (files for $250 mln mixed securities shelf offering)

• $HP Inc(HPQ.US)$ -4% (downgraded to Underweight from Equal-Weight at Morgan Stanley)

• $Dell Technologies(DELL.US)$ -3.3% (downgraded to Equal-Weight from Overweight at Morgan Stanley)

• $Advanced Micro Devices(AMD.US)$ -2.3% (downgraded to Equal Weight from Overweight at Barclays)

• $Hub Group(HUBG.US)$ -0.9% (downgraded to Equal-Weight from Overweight at Stephens)